Neuroengineering: 5,376-Channel Neural Recording

Advancing neural interfaces requires large-scale, high-density recording technologies capable of capturing full-spectrum neural activity across cortical and subcortical regions. In this work, we present a scalable neural recording and stimulation platform through co-optimization of ASIC design, flexible electrode array fabrication, and packaging. Our system features three key elements: (1) a compact ASIC with 5376 simultaneous recording channels and an FPGA backend, capable of raw, full-bandwidth data acquisition; (2) high-density, flexible µECoG electrode arrays for brain mapping in rodents and humans; and (3) a scalable, high-yield bonding method for integrating high-density electrode arrays with ASICs. This system was further validated through in vivo high-density µECoG recordings in rats.